Inclusion and Exclusion Criteria

Inclusion Criteria

  • Adults aged ≥ 18 years diagnosed with head and neck cancer (HNC)
  • Capacity to provide informed written consent
  • Histological diagnosis of squamous cell carcinoma of the oral cavity, oropharynx, nasopharynx, larynx, hypopharynx or unknown squamous cell primary of head and neck origin histologically confirmed
  •  (C)RT patients discussed in a Head and Neck MDT meeting and deemed medically fit for an agreed treatment plan for primary or adjuvant radiotherapy ± concurrent or induction chemotherapy (cisplatin or cetuximab)
  • Patients planned to receive a minimum of 60Gy to a defined clinical target volume in the oral cavity or oropharynx, or neck levels Ia/b as defined by the current RTOG criteria

Exclusion Criteria

  • Known to be pregnant or planning to become pregnant within the trial treatment period
  • Photosensitive Epilepsy
  • Parotid tumours
  • Previous radiotherapy for HNC
  • Current/ongoing oral mucositis (OM) and Trismus limiting laser access for treatment
  • Patients who are experiencing active heavy tumour bleeding from the mouth (haemorrhage)
  • Patients for whom the Multi-Disciplinary Team recommend short course palliative radiotherapy
  • Patients on immune suppressant drugs (except low dose steroids)
  • Participation in other trials assessing different treatments for OM
  • Unable to provide written informed consent